Nicklas Bendtner rises highest to head home his first goal in Arsenal's 4-0 FA Cup victory over Leyton Orient.

STORY HIGHLIGHTS

• Arsenal and Manchester City are both through to the quarterfinals of the FA Cup
• Arsenal defeat Leyton Orient 5-0 while Manchester City see off Aston Villa 3-0
• Arsenal now travel to Manchester United in the pick of the last eight ties
• Holders Bayern Munich beaten 1-0 by Schalke in German Cup semifinals

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(CNN) -- Arsenal and Manchester City are both through to the quarterfinals of the FA Cup after comfortable fifth round wins over Leyton Orient and Aston Villa respectively on Wednesday.

Manager Arsene Wenger made 10 changes to his Arsenal side after their Carling Cup final defeat by Birmingham on Sunday, and the Premier League outfit proved too strong for their third-tier opponents as Nicklas Bendtner scored a hat-trick in a 5-0 replay victory.

Moroccan striker Marouane Chamakh opened the scoring in the seventh minute from close range, after some fine play on the right from Tomas Rosicky -- the only player to retain his place from the weekend's Wembley loss.

It was Chamakh's first goal since November and strengthens his claims for a place in the side following Robin van Persie's injury.

Then Bendtner took control, adding a second on the half hour mark when heading in Kieran Gibbs' cross from the left -- and curling home a fine strike from the edge of the area for Arsenal's third.

The Danish striker completed his hat-trick from the penalty spot after Gibbs was fouled in the area.

Gael Clichy netted only his second senior goal to complete the scoring for Arsenal, whose reward is a last eight trip to Manchester United, with the top two sides in the Premier League going head-to-head in the tie of the round.

Meanwhile, Manchester City made short work of Premier League rivals Villa, cruising to a 3-0 success.

Yaya Toure gave City an early lead when netting from close range after Patrick Vieira's header had rebounded off a defender.

And Mario Balotelli doubled their lead in the 25th minute, running on to a long Toure through-ball before superbly lifting his shot beyond goalkeeper Brad Friedel and in off the post.

David Silva completed the scoring for City with a superb drive with just 20 minutes remaining and Roberto Mancini's side now entertain Reading, the only non-Premier League team still in the competition.

Meanwhile, holders Bayern Munich are out of the German Cup, beaten 1-0 by Schalke in Wednesday's second semifinal.

Spanish legend Raul headed home the only goal in the 15th-minute and the Blues will now face second division side Duisburg in May's final in Berlin.

The defeat piles more pressure on Bayern coach Louis van Gaal, with the Champions League their only realistic chance of silverware this season.

And in Scotland, Celtic are through to the last eight of the cup after defeating Glasgow rivals Rangers 1-0 in a typically feisty encounter.

Mark Wilson scored the only goal of the game for the home side, after Rangers had Steven Whittaker sent off.