The Iowa State Cyclones are hot in March.

After winning the Big-12 conference championship and crushing South Dakota State in the opening round, the second-seeded Cyclones continued the momentum to cruise to a 62-51 second round victory over Washington State.

Iowa State Men's Basketball @CycloneMBB

Cue 𝙎𝙬𝙚𝙚𝙩 (16) Caroline!<a href="">#Cyclones</a> | <a href="">#C5C</a> <a href="">

NCAA March Madness @MarchMadnessMBB

THE CYCLONES ARE HEADED TO THE SWEET 16 ‼️<a href="">#MarchMadness</a> <a href="">@CycloneMBB</a> <a href="">

The win allowed Iowa State to advance to the Sweet 16 for the second time in the last three seasons. The win came despite Washington State getting out to an early lead and the team's being tied at 27 at halftime.

Tamin Lipsey led the Cyclones with 15 points while also adding five rebounds and four assists. Curtis Jones had 12 points, three rebounds and three assists off of the bench and Milan Momcilovic and Keshon Gilbert each had 10 points.

Iowa State Men's Basketball @CycloneMBB

Fadeaways is what we do. <a href="">#Cyclones</a> | <a href="">#C5C</a> | <a href="">@AtgTreking</a> <br><br> <a href="">

Iowa State Men's Basketball @CycloneMBB

Tamin Fadeaway Three.<br><br>Rob Fadeaway. <br><br>Clones up 10.<br><br>#2 ISU 56 - #7 WSU 46 | 6:19 2nd Half<a href="">#Cyclones</a> | <a href="">#C5C</a> <a href="">

Fans took to social media to celebrate the accomplishment and the Cyclones tenacious style of play.

Cyclone Larry @CycloneLarry69

TJ Otzelberger now has as many Sweet 16s in his first 3 season at Iowa State as the Iowa Hawkeyes have in the last 37 years

J_Allen @TheRealJ_Allen

Iowa State is now the premier basketball brand in the B12 now. Let that sink in. 😔

NKY Bracket Guy @BracketNky

Between Iowa State &amp; Baylor, I really think the Big 12 is becoming a 5 headed monster (Kansas/Arizona/Houston).<br><br>Realignment hurt them for FB, but they are THE premier basketball conference until otherwise noted😅😅

Cowboy Adama 🤠 @uconnfan07

Is Iowa State really good defensively? Yes. Are we also so much better than Washington State on both ends of the floor? Also yes.

Father Kyle Kempt @kylekempt

I think I'd sink into the earth if I had to play against Iowa State's defense for a full 40

Alex Mueller @AlexMueller23

Refs and calls whatever, Iowa State absolutely shut Jaylen down that half. Gotta give them credit

Sean Paul @SeanPaulCBB

Iowa State is the best defense in the country. Even better than Houston imo. Just a suffocating defense who forces such tough passes and contests everything. Nothing easy facing the Clones', who are 2:03 away from the Sweet 16.

⚜️Alan Thomas⚜️ @CardN_AL

Iowa State might be the best team in the country.

Reggie B Sports @reggiebsports

Iowa State is the new Virginia of college basketball. Hold the ball and play great D.

The win sets up a game against the winner of Duquesne and Illinois. The Cyclones did not face either team in the regular season. The Cyclones are 3-12 all-time against the Fighting Illini, with the last matchup coming in 2018. The Cyclones have never faced Duquesne in program history.